ITI and Resuming Prophylaxis

• After 6 months, Reggie's inhibitor titer was determined to be 4 BU and ITI with rFVIII was increased to 200 IU/kg per day
• The inhibitor peaked at 55 BU but then gradually fell over 18 months of continuous treatment, with only 7 days without ITI doses during that timeframe
• ITI was deemed successful and Reggie returned to a similar rFVIII prophylaxis regimen to that which he received prior to discontinuation at age 18

 

Mark T. Reding, MD Associate Professor of Medicine Director, Center for Bleeding and Clotting Disorders University of Minnesota Medical Center